Pharmacist developed & tested METHIRAS-5
Tablet

METHIRAS-5

Methiras-5 Tablet is a combination antidiabetic formulation containing Glibenclamide 5 mg and Metformin Hydrochloride 500 mg (Sustained Release). It is used as an adjunct to diet and exercise for the management of Type 2 diabetes mellitus.

Glibenclamide 5mg + Metformin HCl 500mg SR
Anti-diabetic
Tablet
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Medicine Information

Product information:

Methiras-5 Tablet is a combination antidiabetic formulation containing Glibenclamide 5 mg and Metformin Hydrochloride 500 mg (Sustained Release). It is used as an adjunct to diet and exercise for the management of Type 2 diabetes mellitus.

Glibenclamide helps stimulate insulin release from the pancreas, while Metformin helps reduce glucose production by the liver and improves the body's sensitivity to insulin.

Key Benefits:

  • Metformin improves insulin sensitivity and reduces hepatic glucose output, while Glibenclamide stimulates pancreatic β‑cells to release insulin.
  • Combination therapy ensures balanced control of both fasting and post‑meal blood sugar levels.
  • Sustained glycemic control reduces long‑term diabetes complications.
  • Addresses both insulin resistance and insulin deficiency in type 2 diabetes.
  • Often prescribed when monotherapy is insufficient for glycemic control.
  • Metformin SR formulation provides prolonged action with reduced gastrointestinal side effects.

Directions for use:

Take Methiras-5 Tablet exactly as prescribed by a registered medical practitioner. It is generally taken with meals to reduce gastrointestinal discomfort and support consistent blood glucose control. Swallow the sustained-release tablet whole with water; do not crush, chew, or break it.

Storage and Safety Information:

  • Store in a cool, dry place, protected from moisture and direct sunlight.
  • Keep out of reach of children.
  • Use only under the supervision of a qualified healthcare professional.
  • Glibenclamide may cause hypoglycaemia (low blood sugar). Be aware of symptoms such as sweating, dizziness, shakiness, hunger, or confusion.
  • Metformin may rarely cause a serious condition called lactic acidosis; inform your doctor if you have significant kidney or liver problems.
  • Regular monitoring of blood glucose and kidney function may be recommended during treatment.
  • Inform your doctor about any existing medical conditions and all medicines or supplements you are taking.
  • Use during pregnancy or breastfeeding only on the advice of a qualified healthcare professional.

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